What is Characteristics Mesothelioma Biphasic?

Biphasic Mesothelioma Characteristics

Malignant mesothelioma is a cancer that is defined by the presence of malignant cells membrane called pleura, located next to the chest cavity coating the lungs. Cancer cells can also be located in the peritoneum, which is the tissue surrounding the abdominal organs and it and the membrane of the heart, the pericardium. It's type of cancer is very rare.

Those at risk of malignant mesothelioma are people who somehow have inhaled asbestos at work at home, or those who lived with people who worked around asbestos. Most cases of mesothelioma are not diagnosed until late and when they have spent 20 or 50 years before the first symptoms appear. Some of these symptoms are shortness of breath, weight loss, lumps in the abdomen, pain under the ribs, and swelling or pain in the abdomen.

Biphasic malignant mesothelioma

One of the main forms of malignant mesothelioma is a biphasic manner. The biphasic malignant mesothelioma accounts for 30 or 40% of cases of malignant mesothelioma. It is a mixture of two other forms of mesothelioma, epithelial and sarcomatoid. When a person is diagnosed with this disease will be diagnosed with both mesothelioma, epithelial and sarcomatoid.

Diagnosing the Mesothelioma Biphasic

Mesothelioma is diagnosed through medical tests and the use of imaging tests. Other tests that may be performed include blood tests, bronchoscopy and biopsy. The cells of malignant mesothelioma are classified into three categories histological epithelial -mesotelioma, biphasic mesothelioma, sarcomatoid mesothelioma and, biphasic mesothelioma

For the specific form of biphasic mesothelioma, to diagnose it properly, you must discard question of other cancers that contain similar features like synovial sarcomas and carcinomas. To do this, there are techniques to identify and label specific proteins that exist in cells, such as immunohistochemical test that can be performed to distinguish this disease compared to other forms of cancer.

Since the cells are very small and both the sarcomatoid cells and epithelial cells have the ability to be present in different areas of the tumor, it is difficult to diagnose and detect the biphasic mesothelioma. Given this knowledge, the best way to get a correct diagnosis, assessing substantial amount of tissue that is affected. Take a sample, similar to that taken in biopsies, is a good way to determine the type of tumor.



Treatment of Maglinant Biphasic
The treatment of malignant biphasic mesothelioma is different from other more simple types as will vary depending on the ratio of sarcomatoid epithelial cells that are present. Since sarcomatoid are typically more aggressive epithelial, patients diagnosed with biphasic mesothelioma with low levels of sarcomatoid cells tend to have better results. There are two types of treatment:

1.Traditional Treatments

Traditional treatments include chemotherapy, radiation and surgery. These treatments are usually combined to achieve better results and increase life expectancy. The chosen combination of treatments will depend on the stage of the cancer.
The type of surgery to be carried out as a treatment of malignant mesothelioma include drastic procedures such as removal of the affected part of the lung and the chest layer surrounding it. Less drastic is the process of draining the fluid surrounding the lung and can cause pain and pressure.

2.New Treatments
Some new treatments for mesothelioma include gene therapy, immunotherapy and photodynamic therapy, new chemotherapeutic agents and radiation therapy modulated. Currently these treatments are not as successful as traditional treatments but over time as more are developed to achieve those results

3.Additional Treatment Methods
Along with new forms of treatment mentioned above, are being tested more radical for biphasic, such as angiogenesis therapies, malignant mesothelioma treatments interferon and interleukin therapy and many clinical trials. Investigations are studying the effectiveness of alternative, such as the use of herbs, special diets, acupuncture, homeopathic medicine, large doses of vitamin C and therapeutic massage treatments.

References:
American Cancer Society
Mayo Clinic

Posted by Alfiansyah

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